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WHO Classification of Tumours
Undifferentiated carcinoma
Gallbladder and extrahepatic biliary tract


Undifferentiated carcinoma is a usually aggressive, malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or urothelial cell differentiation.

Undifferentiation or poorly differentiated carcinoma of the gallbladder and extrahepatic biliary tract
This neoplasm is more common in the gallbladder than in the extrahepatic bile ducts. Characteristically, glandular structures are few or absent. There are several histological variants: spindle cell, giant cell (including those with osteoclast- like giant cells), small cell (nonneuroendocrine), and a nodular/lobular type that superficially resembles breast carcinoma

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000

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Albores-Saavedra J, Molberg K, Henson DE (1996)
Unusual malignant epithelial tumors of the gallbladder.
Semin Diagn Pathol 13: 326-38

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Diebold-Berger S, Vaiton JC, Pache JC, d'Amore ES (1995)
Undifferentiated carcinoma of the gallbladder. Report of a case with immunohistochemical findings.
Arch Pathol Lab Med 119: 279-82

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Guo KJ, Yamaguchi K, Enjoji M (1988)
Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis.
Cancer 61: 1872-9

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Haratake J, Yamada H, Horie A, Inokuma T (1992)
Giant cell tumor-like cholangiocarcinoma associated with systemic cholelithiasis.
Cancer 69: 2444-8

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Nakanishi Y, Ito T, Kubota K, Takeda H, Yonemori A, Kawakami H, Zen Y, Kondo S (2007)
Spindle cell-type undifferentiated carcinoma of the common bile duct of the hepatic hilus: report of a case.
Surg Today 37: 708-12

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Nishihara K, Tsuneyoshi M (1993)
Undifferentiated spindle cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases.
Hum Pathol 24: 1298-305


The recently described benign giant cell tumour of the biliary tree, a true histiocytic neoplasm, can be distinguished from carcinoma with osteoclast-like giant cells by immunohistochemical assessment of CD163, CD68, HAM56, and keratins

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Albores-Saavedra J, Grider DJ, Wu J, Henson DE, Goodman ZD (2006)
Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells.
Am J Surg Pathol 30: 495-500

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010