logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Squamous cell carcinoma, NOS
Gallbladder and extrahepatic biliary tract


Definition

A carcinoma arising from squamous epithelial cells, morphologically characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Typical sites of squamous cell carcinomas include the head and neck region, repiratory tract, skin and cervix.

Squamous cell carcinoma of the gallbladder and extrahepatic bile ducts
This malignant epithelial neoplasm is composed entirely of squamous cells with highly variable degrees of differentiation. Keratinizing and nonkeratinizing types exist

Click to access Pubmed
Aranha GV, Reyes CV, Greenlee HB, Field T, Brosnan J (1980)
Squamous cell carcinoma of the proximal bile duct--a case report.
J Surg Oncol 15: 29-35




Click to access Pubmed
Gatof D, Chen YK, Shah RJ (2004)
Primary squamous cell carcinoma of the bile duct diagnosed by transpapillary cholangioscopy: case report and review.
Gastrointest Endosc 60: 300-4




Click to access Pubmed
Suster S, Huszar M, Herczeg E, Bubis JJ (1987)
Adenosquamous carcinoma of the gallbladder with spindle cell features. A light microscopic and immunocytochemical study of a case.
Histopathology 11: 209-14



. Spindle cells predominate in some poorly differentiated squamous cell carcinomas, which may be confused with sarcomas
Click to access Pubmed
Suster S, Huszar M, Herczeg E, Bubis JJ (1987)
Adenosquamous carcinoma of the gallbladder with spindle cell features. A light microscopic and immunocytochemical study of a case.
Histopathology 11: 209-14



. Immunolabelling for keratin and p63 may clarify the diagnosis in these spindle-cell cases. The carcinoma may arise from areas of squamous metaplasia or high-grade intraepithelial neoplasia
Click for details
Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000



. Most gallbladder carcinomas with squamous differentiation represent adenosquamous carcinomas, and the glandular component may be very focal; thorough examination is required before a diagnosis of pure squamous cell carcinoma can be established
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.