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WHO Classification of Tumours
Adenosquamous carcinoma
Gallbladder and extrahepatic biliary tract


A carcinoma composed of malignant glandular cells and malignant squamous cells.

Adenosquamous carcinoma of the gallbladder
The extent of differentiation of the two malignant components, glandular and squamous, varies, but in general they tend to be moderately differentiated

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Akcali Z, Ozyilkan O, Sakalli H, Bal N, Noyan T (2005)
Gallbladder adenosquamous cell carcinoma: report of two cases.
Acta Gastroenterol Belg 68: 440-2

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Albores-Saavedra J, Grider DJ, Wu J, Henson DE, Goodman ZD (2006)
Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells.
Am J Surg Pathol 30: 495-500

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Chan KM, Yu MC, Lee WC, Jan YY, Chen MF (2007)
Adenosquamous/squamous cell carcinoma of the gallbladder.
J Surg Oncol 95: 129-34

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Lim SH, Yang HW, Kim A, Cha SW, Jung SH, Go H, Lee WC (2007)
Adenosquamous carcinoma of extrahepatic bile duct: a case report.
Korean J Intern Med 22: 206-10

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Mingoli A, Brachini G, Petroni R, Antoniozzi A, Cavaliere F, Simonelli L, Chirletti P, Modini C (2005)
Squamous and adenosquamous cell carcinomas of the gallbladder.
J Exp Clin Cancer Res 24: 143-50

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Nishihara K, Nagai E, Izumi Y, Yamaguchi K, Tsuneyoshi M (1994)
Adenosquamous carcinoma of the gallbladder: a clinicopathological, immunohistochemical and flow-cytometric study of twenty cases.
Jpn J Cancer Res 85: 389-99

. Keratin pearls are often present in the squamous component, and mucin is usually demonstrable in the neoplastic glands.