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WHO Classification of Tumours
Signet ring cell carcinoma
Gallbladder and extrahepatic biliary tract


A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus.

Signet ring cell carcinoma of the gallbladder
Cells containing intracytoplasmic mucin displacing the nuclei toward the periphery predominate in this variant of adenocarcinoma. A variable amount of extracellular mucin is usually present. Lateral spread through the lamina propria is a common feature. A diffusely infiltrating linear pattern resembling linitis plastica (diffuse-type adenocarcinoma) of the stomach has been observed

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010