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WHO Classification of Tumours
Mucinous adenocarcinoma
Gallbladder and extrahepatic biliary tract


Definition

An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation.

Mucinous adenocarcinoma of the gallbladder
These neoplasms are more common in the gallbladder than in the extrahepatic bile ducts, and are similar to those that arise at other anatomical sites. By convention, > 50% of the tumour contains extracellular mucin

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000




Click for details
Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000



. Mucinous carcinoma should be distinguished from a benign mucocele. The abundant extracellular mucin present in a mucocele may be recognized grossly in the gallbladder wall as nodules of different sizes. The mucin can extend to the serosa through the Rokitansky-Aschoff sinuses and induce a histiocytic response. The histiocytes may phagocytize mucin and be confused with signet ring cells. Immunolabelling for keratin and CEA is positive in mucinous carcinoma and negative in mucocele. Ruptured, mucin-containing, Rokitansky-Aschoff sinuses with abundant extracellular mucins having small benign glandular and papillary structures should not be confused with mucinous carcinoma
Click to access Pubmed
Albores-Saavedra J, Galliani C, Chable-Montero F, Batich K, Henson DE (2009)
Mucin-containing Rokitansky-Aschoff sinuses with extracellular mucin deposits simulating mucinous carcinoma of the gallbladder.
Am J Surg Pathol 33: 1633-8




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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