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WHO Classification of Tumours
Adenocarcinoma, intestinal type
Gallbladder and extrahepatic biliary tract


A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
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Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000


In the gallbladder, two morphological variants have been described

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

> Tubular cell variant
> Goblet cell variant