Adenocarcinoma, intestinal type
Gallbladder and extrahepatic biliary tract
A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
IARC Press: Lyon 2000
In the gallbladder, two morphological variants have been described
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
International Agency for Research on Cancer: Lyon 2010
> Tubular cell variant
> Goblet cell variant