logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Adenoma, NOS
Gallbladder and extrahepatic biliary tract


Definition

A non-invasice, benign neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated. The neoplastic epithelial cells may or may not display moderate cellular atypia or dysplasia. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.

Adenoma of the gallbladder
Adenomas are benign neoplasms of glandular epithelium that are typically polypoid, single and well-demarcated. They are more common in women than in men, and most occur in adults

Click to access Pubmed
Albores-Saavedra J, Vardaman CJ, Vuitch F (1993)
Non-neoplastic polypoid lesions and adenomas of the gallbladder.
Pathol Annu 28 Pt 1: 145-77




Click to access Pubmed
Wistuba II, Miquel JF, Gazdar AF, Albores-Saavedra J (1999)
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Hum Pathol 30: 21-5



. They are found in 0.30.5% of gallbladders removed for cholelithiasis or chronic cholecystitis. Adenomas are often small, asymptomatic, and usually discovered incidentally during cholecystectomy, but they can be multiple, fill the lumen of the gallbladder and be symptomatic. Occasionally, adenomas of the gallbladder occur in association with Peutz-Jeghers syndrome
Click to access Pubmed
Foster DR, Foster DB (1980)
Gall-bladder polyps in Peutz-Jeghers syndrome.
Postgrad Med J 56: 373-6



or Gardner syndrome
Click to access Pubmed
Tantachamrun T, Borvonsombat S, Theetranont C (1979)
Gardner's syndrome associated with adenomatous polyp of gall bladder: report of a case.
J Med Assoc Thai 62: 441-7




Click to access Pubmed
Walsh N, Qizilbash A, Banerjee R, Waugh GA (1987)
Biliary neoplasia in Gardner's syndrome.
Arch Pathol Lab Med 111: 76-7



. While a significant number of adenomas in the gallbladder are associated with lithiasis, those of the extrahepatic bile ducts are not. A small proportion of adenomas progress to invasive carcinoma
Click to access Pubmed
Albores-Saavedra J, Vardaman CJ, Vuitch F (1993)
Non-neoplastic polypoid lesions and adenomas of the gallbladder.
Pathol Annu 28 Pt 1: 145-77




Click to access Pubmed
Kijima H, Watanabe H, Iwafuchi M, Ishihara N (1989)
Histogenesis of gallbladder carcinoma from investigation of early carcinoma and microcarcinoma.
Acta Pathol Jpn 39: 235-44



.

> Histological subtypes
Tubular adenoma
Papillary adenoma
Tubulovillous adenoma

> Cell types
Pyloric-gland type
Intestinal type
Foveolar type
Biliary type