Liver and intrahepatic bile ducts
A malignant neoplasm characterized by a vascular proliferation which usually contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin deposition are frequently present. It preferentially develops in people with compromised immune systems including those with the acquired immune deficiency syndrome (AIDS). Disseminated Kaposi sarcoma involving the liver is usually an incidental finding on autopsy detected in 15% of patients with AIDS.
Hepatic Kaposi sarcoma typically involves portal and periportal areas, often grossly detectable as red-brownish foci. Histologically, these tumours typically show poorly vasoformative spindle-cell proliferation accompanied by haemorrhage and focal deposition of haemosiderin. Cytoplasmic eosinophilic hyaline globules are a typical finding, and immunohistochemical demonstration of membranous/cytoplasmic CD31 and CD34, and nuclear human herpesvirus 8 (HHV-8) are diagnostic
Noel JC, Hermans P, Andre J, Fayt I, Simonart T, Verhest A, Haot J, Burny A (1996)
Herpesvirus-like DNA sequences and Kaposi's sarcoma: relationship with epidemiology, clinical spectrum, and histologic features.
Cancer 77: 2132-6
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
International Agency for Research on Cancer: Lyon 2010
|Gross lesions : multiple dark-brown lesions centred in large portal areas|
|Histopathology: Spindle cells and slit-like vascular spaces|