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WHO Classification of Tumours
Undifferentiated carcinoma
Liver and intrahepatic bile ducts


Definition

Undifferentiated carcinoma is a usually aggressive, malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or urothelial cell differentiation.

Undifferentiated hepatic carcinomas are tumours that are primary to the liver and can be diagnosed as carcinomas based on immunohistochemistry, but cannot be further classified. Undifferentiated carcinoma is rare, accounting for < 2% of epithelial liver tumours. There is a male preponderance, but data on geographical distribution are not available. Localization, clinical features, symptoms and signs, and diagnostic procedures display no differences compared with hepatocellular carcinoma. Undifferentiated carcinomas are postulated to have a worse prognosis (compared with HCC), although greater case numbers to support this are not available

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Craig JR, Peters RL, and Edmondson HA
Tumours of the Liver and Intrahepatic Bile Ducts
Armed Forces Institute of Pathology
Washington, DC. 1989




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Ishak KG, Anthony PP, and Sobin LH
Histological Typing of Tumours of the Liver
Springer: Berlin, Heidelberg, New York, Tokyo 1999



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