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WHO Classification of Tumours
Hepatosplenic T-cell lymphoma
Liver and intrahepatic bile ducts


Hepatosplenic T-cell lymphoma (HSTL) is an aggressive extranodal and systemic neoplasm derived from cytotoxic T-cells, usually of γδ T-cell receptor type. It is typically composed of medium-sized lymphoid cells with marked sinusoidal infiltration of spleen, liver and bone marrow (BM)
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008