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WHO Classification of Tumours
Undifferentiated carcinoma
Colon and rectum


Undifferentiated carcinoma is a usually aggressive, malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or urothelial cell differentiation.

Undifferentiated carcinoma of the colon and rectum
These rare tumours lack morphological, immunohistochemical, and molecular biological evidence of differentiation beyond that of an epithelial tumour and have variable histological features. Some of these tumours have MSI-H

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010