Medullary carcinoma, NOS
Colon and rectum
A malignant epithelial tumour in which the cells form solid sheets and have abundant eosinophilic cytoplasm and large, vesicular nuclei with prominent nucleoli. An intraepithelial infiltrate of lymphocytes is characteristic. Typical sites of involvemet include carcinomas thyroid gland, breast, colon, rectum, and small intestine.
Medullary carcinoma of the colon and rectum
This rare variant is characterized by sheets of malignant cells with vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm exhibiting prominent infiltration by intraepithelial lymphocytes. It almost invariably has MSI-H and usually a favourable prognosis
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