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WHO Classification of Tumours
Medullary carcinoma, NOS
Colon and rectum


Definition

A malignant epithelial tumour in which the cells form solid sheets and have abundant eosinophilic cytoplasm and large, vesicular nuclei with prominent nucleoli. An intraepithelial infiltrate of lymphocytes is characteristic. Typical sites of involvemet include carcinomas thyroid gland, breast, colon, rectum, and small intestine.

Medullary carcinoma of the colon and rectum
This rare variant is characterized by sheets of malignant cells with vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm exhibiting prominent infiltration by intraepithelial lymphocytes. It almost invariably has MSI-H and usually a favourable prognosis

Click to access Pubmed
Kirchner T, Reu S (2008)
[Development of molecular-pathologic entities of colorectal cancer].
Pathologe 29 Suppl 2: 264-9




Click to access Pubmed
Selves J (2009)
[Histological types and prognostic factors in colorectal cancer].
Med Sci (Paris) 25 Spec No 1: 9-12




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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