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WHO Classification of Tumours
Traditional serrated adenoma
Colon and rectum


Definition

Traditional serrated adenoma (TSA) are preferentially (>80%) located in the distal colon, particularly the rectosigmoid region
Click to access Pubmed
Li SC, Burgart L (2007)
Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.
Arch Pathol Lab Med 131: 440-5



, are typically protuberant or pedunculated, and measure less than 1.5 cm in diameter. They show histological features of dysplasia (enlargement, variation of nuclear size and shape, nuclear hyperchromasia, and irregular nuclear polarity), and have eosinophilic cytoplasm with serration
Click to access Pubmed
Li SC, Burgart L (2007)
Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.
Arch Pathol Lab Med 131: 440-5




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. They are usually asymptomatic. The clinical implications of serration in adenomas and of sessile serrated adenomas/polyps are not yet well-defined
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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