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WHO Classification of Tumours
Leiomyosarcoma, NOS
Small intestine


Definition

Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Intestinal leiomyosarcomas
They are rare as leiomyomas. Prognosis is better when grade and mitotic rate are low

Click to access Pubmed
Miettinen M, Sobin LH, Lasota J (2009)
True smooth muscle tumors of the small intestine: a clinicopathologic, immunhistochemical, and molecular genetic study of 25 cases.
Am J Surg Pathol 33: 430-6




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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