Gastrointestinal stromal tumor, NOS
The term gastrointestinal stromal tumour (GIST) is used for a specific group of tumours comprising the majority of gastrointestinal mesenchymal tumours, including those previously termed leiomyoma, cellular leiomyoma, leiomyoblastoma and leiomyosarcoma
Hamilton SR, Aaltonen LA (Eds.)
. Rare cases involving tissues outside the gastrointestinal tract have also been reported (extragastrointestinal gastrointestinal stromal tumors).
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
IARC Press: Lyon 2000
GIST are KIT-expressing and KIT-signaling-driven mesenchymal tumors that repsond favourably to treatment with the KIT tyrosine kinase inhibitor imatinib mesylate / Gleevec
Druker BJ (2004)
Imatinib as a paradigm of targeted therapies.
Adv Cancer Res 91: 1-30
Small intestinal and duodenal GISTs comprise about 30% and 5%, respectively, of all GISTs
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
International Agency for Research on Cancer: Lyon 2010