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WHO Classification of Tumours
Gastrointestinal stromal tumor, NOS
Small intestine


Definition

The term gastrointestinal stromal tumour (GIST) is used for a specific group of tumours comprising the majority of gastrointestinal mesenchymal tumours, including those previously termed leiomyoma, cellular leiomyoma, leiomyoblastoma and leiomyosarcoma
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Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



. Rare cases involving tissues outside the gastrointestinal tract have also been reported (extragastrointestinal gastrointestinal stromal tumors).
GIST are KIT-expressing and KIT-signaling-driven mesenchymal tumors that repsond favourably to treatment with the KIT tyrosine kinase inhibitor imatinib mesylate / Gleevec

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Druker BJ (2004)
Imatinib as a paradigm of targeted therapies.
Adv Cancer Res 91: 1-30



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Small intestinal and duodenal GISTs comprise about 30% and 5%, respectively, of all GISTs

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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