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WHO Classification of Tumours
Adenocarcinoma, NOS
Small intestine


Definition

A common, malignant tumour characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreted product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell adenocarcinoma, hepatocellular carcinoma, colon adenocarcinoma, and prostate adenocarcinoma.

Adenocarcinoma of the small intestine
This tumour is rare and mainly seen in the duodenum, especially in the region of the ampulla of Vater. Men are affected slightly more often than women, and the incidence in African Americans is about twice that in Whites

Click to access Pubmed
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD (2009)
The epidemiology and pathogenesis of neoplasia in the small intestine.
Ann Epidemiol 19: 58-69



; the median age at manifestation is approximately 67 years. The model of the adenoma–carcinoma sequence is believed to apply to the small intestine as well as the large intestine. Risk factors include chronic inflammation, in particular Crohn and coeliac diseases, smoking and alcohol consumption. Clinical signs include gastrointestinal bleeding and anaemina, bowel obstruction, abdominal pain, vomiting, weight loss, jaundice when located in the region of the ampulla of Vater. They may perforate leading to peritonitis and/or carcinomatosis. The overall 5-year survival reported is 27%
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Key C, Meisner A
Cancers of the esophagus, stomach, and small intestine. In: Surveillance, Epidemiology, and End Results (SEER) Survival Monograph: Cancer Survival Among Adults-US SEER Program, 1988-2001: Patient and Tumor Characteristics
National Cancer Institute: Bethesda, MD 2007



and 30.5%
Click to access Pubmed
Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999)
The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the National Cancer Data Base, 1985-1995.
Cancer 86: 2693-706



and the median survival of 13.9 month
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Key C, Meisner A
Cancers of the esophagus, stomach, and small intestine. In: Surveillance, Epidemiology, and End Results (SEER) Survival Monograph: Cancer Survival Among Adults-US SEER Program, 1988-2001: Patient and Tumor Characteristics
National Cancer Institute: Bethesda, MD 2007



and 19.7 months
Click to access Pubmed
Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999)
The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the National Cancer Data Base, 1985-1995.
Cancer 86: 2693-706



.

> Histological subtypes
Mucinous adenocarcinoma
Signet ring cell carcinoma