logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Gastrointestinal stromal tumor, NOS
Stomach


Definition

The term gastrointestinal stromal tumour (GIST) is used for a specific group of tumours comprising the majority of gastrointestinal mesenchymal tumours, including those previously termed leiomyoma, cellular leiomyoma, leiomyoblastoma and leiomyosarcoma
Click for details
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



. Rare cases involving tissues outside the gastrointestinal tract have also been reported (extragastrointestinal gastrointestinal stromal tumors).

Gastric GIST
Approximately 60% of GISTs arise in the stomach

Click to access Pubmed
Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG (2005)
Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden.
Cancer 103: 821-9



; they are the most common primary mesenchymal tumour of the gastrointestinal tract GIST spans a clinical spectrum from benign to malignant; it has been estimated that about 25% of gastric GISTs (not counting minimal incidental tumours) are clinically malignant. The median age at manifestation is 60-65 years. GIST are KIT-expressing and KIT signaling-driven mesenchymal tumors respond favourably to treatment with the KIT tyrosine kinase inhibitor imatinib mesylate / gleevec
Click to access Pubmed
Druker BJ (2004)
Imatinib as a paradigm of targeted therapies.
Adv Cancer Res 91: 1-30



.