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WHO Classification of Tumours
Gastrointestinal stromal tumor, NOS


The term gastrointestinal stromal tumour (GIST) is used for a specific group of tumours comprising the majority of gastrointestinal mesenchymal tumours, including those previously termed leiomyoma, cellular leiomyoma, leiomyoblastoma and leiomyosarcoma
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Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000

. Rare cases involving tissues outside the gastrointestinal tract have also been reported (extragastrointestinal gastrointestinal stromal tumors).

Gastric GIST
Approximately 60% of GISTs arise in the stomach

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Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG (2005)
Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden.
Cancer 103: 821-9

; they are the most common primary mesenchymal tumour of the gastrointestinal tract GIST spans a clinical spectrum from benign to malignant; it has been estimated that about 25% of gastric GISTs (not counting minimal incidental tumours) are clinically malignant. The median age at manifestation is 60-65 years. GIST are KIT-expressing and KIT signaling-driven mesenchymal tumors respond favourably to treatment with the KIT tyrosine kinase inhibitor imatinib mesylate / gleevec
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Druker BJ (2004)
Imatinib as a paradigm of targeted therapies.
Adv Cancer Res 91: 1-30