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WHO Classification of Tumours
Leiomyosarcoma, NOS
Stomach


Definition

Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Smooth-muscle tumours with atypia and mitotic activity are designated leiomyosarcomas, and such tumours are distinctly rare in the stomach. Cases with ambiguous criteria of malignancy should be designated as having uncertain malignant potential, and complete excision and follow-up is necessary.