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WHO Classification of Tumours
Granular cell tumor, NOS


Granular cell tumour (GCT) is an unusual, benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. This tumour was originally thought to originate from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells.
GCT can arise in any site of the body, including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast, and usually presents as a solitary mass. A minority of patients have multiple tumours. Women are more often affected than men

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Ordonez NG (1999)
Granular cell tumor: a review and update.
Adv Anat Pathol 6: 186-203


Gastric localization is very rare. Gastric GCTs can be solitary or, more frequently, associated with other gastrointestinal localization. Although GCTs are usually clinically and histologically benign, some malignant cases have been reported

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Patti R, Almasio PL, Di Vita G (2006)
Granular cell tumor of stomach: a case report and review of literature.
World J Gastroenterol 12: 3442-5