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WHO Classification of Tumours
Papillary adenocarcinoma, NOS


Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.

Papillary adenocarcinoma of the stomach is a well-differentiated exophytic carcinoma with elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores. The cells tend to maintain their polarity. Some tumours show tubular (papillotubular) differentiation. Rarely, micropapillary architecture is present. The degree of cellular atypia and mitotic index vary; there may be severe nuclear atypia. The invading edge of the tumour is usually sharply demarcated; the tumour may be infiltrated by acute and chronic inflammatory cells.