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WHO Classification of Tumours
Diffuse large B-cell lymphoma (DLBCL), NOS


Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin lymphoma, representing 30%-40% of cases. It consists of a diffuse proliferation of large neoplastic B-cells without significant admixture of centrocytes. It affects mainly adults, with a mean age of manifestation in the 7th decade. The majority of DLBCLs originates primarily in lymph nodes, but up to 40% are initially confined to extranodal sites
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008


Primary gastric DLBCL (PG-DLBCL)
This term is used for tumours that are localized to the stomach at presentation. PG-DLBCL may arise de novo or more rarely from transformation of a prior MALT lymphoma. The term “highgrade MALT lymphoma” should be avoided. DLBCLs are aggressive but potentially curable with multiagent chemotherapy.