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WHO Classification of Tumours
Melanoma, NOS
Esophagus


Definition

Melanoma is a malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.

Cases of melanoma of the oesophagus typically arise in the middle or distal oesophagus of older adults

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Li B, Lei W, Shao K, Zhang C, Chen Z, Shi S, He J (2007)
Characteristics and prognosis of primary malignant melanoma of the esophagus.
Melanoma Res 17: 239-42




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Sanchez AA, Wu TT, Prieto VG, Rashid A, Hamilton SR, Wang H (2008)
Comparison of primary and metastatic malignant melanoma of the esophagus: clinicopathologic review of 10 cases.
Arch Pathol Lab Med 132: 1623-9



. The most common clinical complaint is dysphagia. At endoscopy, the neoplasms are polypoid and melanin pigmentation is seen in almost all cases
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Fredricks JR, Bejarano PA (2008)
Primary malignant melanoma of the esophagus with separate foci of melanoma in situ and atypical melanocytic hyperplasia in a patient positive for human immunodeficiency virus: a case report and review of the literature.
Arch Pathol Lab Med 132: 1675-8




Click to access Pubmed
Sanchez AA, Wu TT, Prieto VG, Rashid A, Hamilton SR, Wang H (2008)
Comparison of primary and metastatic malignant melanoma of the esophagus: clinicopathologic review of 10 cases.
Arch Pathol Lab Med 132: 1623-9




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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