Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma
, myxoid leiomyosarcoma
, granular cell and inflammatory leiomyosarcoma
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
IARC Press: Lyon 2002
In the oesophagus , malignant smooth-muscle tumours are very rare. They are recognized by a histological resemblance to smooth muscle, nuclear atypia, mitotic activity, and immunohistochemical presence of SMA and desmin. Many reported examples have presented as polypoid intraluminal masses, and prognosis has been poor
Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J (2000)
Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas.
Am J Surg Pathol 24: 211-22