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WHO Classification of Tumours
Leiomyosarcoma, NOS


Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002


In the oesophagus , malignant smooth-muscle tumours are very rare. They are recognized by a histological resemblance to smooth muscle, nuclear atypia, mitotic activity, and immunohistochemical presence of SMA and desmin. Many reported examples have presented as polypoid intraluminal masses, and prognosis has been poor

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Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J (2000)
Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas.
Am J Surg Pathol 24: 211-22