logo logo
Search: Organ site Search: Tumor / Syndrome
WHO Classification of Tumours
Gastrointestinal stromal tumor, malignant


This is a malignant subtype of gastrointestinal stromal tumor characterized by large size (diameter greater than 10cm) and more than 5 mitotic figures per 50 high power fields.

GISTs are very rare in the oesophagus and comprise 1020% of the combined group of smooth-muscle and stromal tumours. Most are clinically detected as intraluminal distal oesophageal masses causing dysphagia, but externally extending oesophageal GISTs can manifest as mediastinal tumours.
Occasional examples have been incidentally detected during radiological screening or surveillance studies, and such tumours can have a good prognosis, an exception among this group of tumours, among which sarcomas predominate

Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010