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WHO Classification of Tumours
Granular cell tumor, NOS


Granular cell tumour (GCT) is an unusual, benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. This tumour was originally thought to originate from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells.
GCT can arise in any site of the body, including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast, and usually presents as a solitary mass. A minority of patients have multiple tumours. Women are more often affected than men

Click to access Pubmed
Ordonez NG (1999)
Granular cell tumor: a review and update.
Adv Anat Pathol 6: 186-203


In the oesophagus, granular cell tumours are usually incidental endoscopic findings in the distal oesophagus and measure <1cm. Rare larger examples can cause dysphagia. Incidence is higher in African Americans, and tumour multiplicity is common, as has been previously observed for granular
cell tumours in soft tissue.