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WHO Classification of Tumours
Squamous cell carcinoma, spindle cell


A poorly differentiated squamous cell carcinoma characterized by a variable presence of malignant cells with spindle cell features.
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Lauwers GY, Grant LD, Scott GV, Carr NJ, Sobin LH (1998)
Spindle cell squamous carcinoma of the esophagus: analysis of ploidy and tumor proliferative activity in a series of 13 cases.
Hum Pathol 29: 863-8

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

. Grossly, it is polypoid, usually involving the middle and lower third of the oesophagus. Microscopically, it is biphasic with epithelial and spindle cells.