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WHO Classification of Tumours
Basaloid squamous cell carcinoma
Esophagus


Definition

A squamous cell carcinoma (SCC) histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.

Basaloid squamous cell carcinoma of the esophagus has a similar appearance to adenoid cystic carcinoma but is more aggressive

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Li TJ, Zhang YX, Wen J, Cowan DF, Hart J, Xiao SY (2004)
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.
Arch Pathol Lab Med 128: 1124-30



. The presence of associated squamous carcinoma in situ is a strong argument for the diagnosis of basaloid carcinoma. Basaloid SCC is a distinct, unusual variant that occurs more commonly in the upper aerodigestive tract
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Banks ER, Frierson HF, Mills SE, George E, Zarbo RJ, Swanson PE (1992)
Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases.
Am J Surg Pathol 16: 939-46




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Tsang WY, Chan JK, Lee KC, Leung AK, Fu YT (1991)
Basaloid-squamous carcinoma of the upper aerodigestive tract and so-called adenoid cystic carcinoma of the oesophagus: the same tumour type?
Histopathology 19: 35-46



. It is more common in older men, who present with dysphagia. Microscopically, it consists of basaloid cells with oval to round nuclei, open pale chromatin, and scant basophilic cytoplasm. It is arranged in solid or cribriform lobules with comedonecrosis
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Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T (2009)
Histological diversity in basaloid squamous cell carcinoma of the esophagus.
Dis Esophagus 22: 231-8



. Areas of squamous intraepithelial neoplasia or conventional SCC are commonly observed
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Wain SL, Kier R, Vollmer RT, Bossen EH (1986)
Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases.
Hum Pathol 17: 1158-66



. Adenoid cystic carcinoma and basaloid squamous cell carcinoma should be distinguished: adenoid cystic carcinoma is less aggressive
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Wain SL, Kier R, Vollmer RT, Bossen EH (1986)
Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases.
Hum Pathol 17: 1158-66



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