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WHO Classification of Tumours
Squamous cell carcinoma, NOS


Squamous cell carcinoma (SCC) of the oesophagus is a malignant epithelial tumour with squamous-cell differentiation, microscopically characterized by keratinocyte-like cells with intercellular bridges and/or keratinization
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

World-wide, SCC is the predominant type of oesophageal carcinoma, affecting preferentially adult men, with tobacco smoking and consumption of hot beverages as major risk factors. In some high incidence regions the occurrrence is declining while in low incidence countries with a Western lifestyle there is a sharp rise in the incidence of oesophageal adenocarcinoma .