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WHO Classification of Tumours
Adenocarcinoma, NOS


A malignant epithelial tumour of the oesophagus with glandular differentiation. These tumours arise predominantly from columnar (“Barrett”) mucosa in the lower third of the oesophagus. Rarely, adenocarcinoma originates from heterotopic gastric mucosa in the upper oesophagus, or from mucosal and submucosal glands
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

Major risk factors for the development of oesophageal adenocarcinomas are gastro-oesophageal reflux disease (GORD) with associated Barrett oesophagus , obesity and and tobacco smoking. The incidence is rising and in many high-resource countries adenocarcinoma is already more frequent than oesophageal squamous cell carcinoma. Males are preferentially affected.