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WHO Classification of Tumours
Neurofibroma, NOS
Hypopharynx, Larynx and Trachea


Definition

An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
Multiple neurofibromas are a hallmark of the neurofibromatosis type 1 (NF1) which is inherited by an autosomal dominant trait.