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WHO Classification of Tumours
Signet ring cell carcinoma
Appendix


Definition

A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus.

If signet-ring cells account for more than 50% of the neoplasm, the term “signet-ring cell carcinoma” is appropriate. Such lesions should be included in the high-grade category

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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