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WHO Classification of Tumours
Adenocarcinoma, NOS


A common, malignant tumour characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreted product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell adenocarcinoma, hepatocellular carcinoma, colon adenocarcinoma, and prostate adenocarcinoma.

Appendiceal adenocarcinoma
This is a malignant epithelial neoplasm with invasion beyond the muscularis mucosae. It occurs in 0.10.2% of appendicectomies, corresponding to an estimated incidence of 0.2 per 100 000 per year. The causes are unclear, however there is an association with neoplasia elsewhere in the large intestine and a preexisting chronic ulcerative colitis may be a risk factor. Elder people are preferentially affected. Clinical outcome depends of tumour grade, stage and histological type, e.g.mucinous versus non-mucinous

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Cortina R, McCormick J, Kolm P, Perry RR (1995)
Management and prognosis of adenocarcinoma of the appendix.
Dis Colon Rectum 38: 848-52

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Nitecki SS, Wolff BG, Schlinkert R, Sarr MG (1994)
The natural history of surgically treated primary adenocarcinoma of the appendix.
Ann Surg 219: 51-7

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Pai RK, Beck AH, Norton JA, Longacre TA (2009)
Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.
Am J Surg Pathol 33: 1425-39

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Smith JW, Kemeny N, Caldwell C, Banner P, Sigurdson E, Huvos A (1992)
Pseudomyxoma peritonei of appendiceal origin. The Memorial Sloan-Kettering Cancer Center experience.
Cancer 70: 396-401


> Histological subtypes
Low-grade appendiceal mucinous neoplasm (LAMN)
Mucinous adenocarcinoma
Signet ring cell carcinoma