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WHO Classification of Tumours
Anaplastic large cell lymphoma, ALK positive
Lip, Oral Cavity and Oropharynx


Definition

Anaplastic large cell lymphoma, ALK-positive, is a T-cell lymphoma consisting of lymphoid cells that are usually large with abundant cytoplasm, pleomorphic, often horseshoe-shaped nuclei, and a translocation involving the ALK gene and expression of ALK protein, and expression of anaplastic lymphoma kinase (ALK) of CD30
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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ALCL, ALK+ accounts for approximately 3% of adult non-Hodgkin lymphomas and 10−20% of childhood lymphomas. It manifests most frequent in the first three decades of life with a male predominance (M:F ratio 1.5:1) and frequent involvement of lymph nodes and extranodal sites.