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WHO Classification of Tumours
Mantle cell lymphoma
Lip, Oral Cavity and Oropharynx


Definition

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as
lymphomatous polyposis.