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WHO Classification of Tumours
Diffuse large B-cell lymphoma (DLBCL), NOS
Tumours of haematopoietic and lymphoid tissues


Definition

Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B lymphoid cells with nuclear size equal to or exceeding normal macrophage nuclei or more than twice the size of a normal lymphocyte, that has a diffuse growth pattern.

Morphological, biological and clinical studies have subdivided diffuse large B-cell lymphomas into morphological variants, molecular and immunophenotypical subgroups and distinct disease entities (Table 10.14). However, a large number of cases remain that may be biologically heterogeneous, but for which there are no clear and accepted criteria for subdivision. These are classified as DLBCL, not otherwise specified (NOS). DLBCL, NOS comprises all DLBCL cases that do not belong to specific subtypes or disease entities mentioned in Table 10.14

> Related Topics
Introduction: Classification of lymphoid neoplasms